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相关概念视频

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

295
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
295

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相关实验视频

Updated: May 20, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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自聚合的长效注射式微晶.

Vivian R Feig1,2,3, Sanghyun Park1,2,4, Pier Giuseppe Rivano1,4,5

  • 1Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.

Nature chemical engineering
|March 27, 2025
PubMed
概括
此摘要是机器生成的。

我们开发了自聚合的长效注射式微晶 (SLIM),以改善药物服药性. SLIM能够在高药负载下进行低不适的注射,这可能有助于提供低成本的避孕药.

关键词:
药物输送是药物输送的过程.用于设备的材料.

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相关实验视频

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科学领域:

  • 生物材料科学 生物材料科学
  • 药品制造 药品制造 药品制造
  • 药物输送系统 药物输送系统

背景情况:

  • 可注射药物库通过剂量简化来提高药物坚持性.
  • 患者接受注射剂受到针尺和相关不适的影响.
  • 注射剂中高药物负载对于持续释放和减少注射体积/不适至关重要.

研究的目的:

  • 开发一种新型的注射配方,SLIM (自聚合长效注射微晶),以解决患者的舒适性和药物递送效率.
  • 为了实现高药物负载,并允许使用低度针 (<25G) 进行注射.
  • 研究自我聚合的机制及其对药物释放动态的影响.

主要方法:

  • 用于在皮下空间自我聚合而设计的药物微晶的配方.
  • SLIM配方的特征,包括药物载荷能力和聚合物与药物比率 (0.0625:1 w/w).
  • 在体外和体内研究,以评估由溶剂交换驱动的自我聚合,并评估动物的长期药物释放.

主要成果:

  • SLIM形成了一个单体植入物,含有最小的聚合物辅助剂,允许高药物负载 (293 mg/ml).
  • 自聚被证实是依赖于溶剂交换的,更慢的交换溶剂导致更密集的植入物.
  • 在体内由于自我聚合机制而观察到长期药物释放的增强.

结论:

  • SLIM技术有助于开发具有高药载荷和低聚合物含量的注射配方.
  • 自聚集性使得可以通过小尺寸针进行注射,从而提高了患者的舒适度.
  • SLIM对具有成本效益的,长效的注射疗法具有前景,特别是在避孕药等应用中.