乳糖类菌对K56对大学生感知压力的影响:一项双盲,随机,安慰剂控制的试验
Yiran Guan1, Ruixin Zhu1, Wen Zhao1
1Key Laboratory of Functional Dairy, Co-Constructed by Ministry of Education and Beijing Government, Department of Nutrition and Health, China Agricultural University, Beijing, China.
益生菌 Lacticaseibacillus paracasei K56补充剂在研究生中降低了压力和焦虑. 这种干预措施还改善了睡眠和调节了肠道微生物群,这表明肠道健康和心理健康之间存在联系.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 研究生面临严重的压力,影响心理健康.
- 益生菌有望通过肠-大脑轴改善心理健康.
研究的目的:
- 为了研究乳酸糖菌菌K56对本科生感知压力的影响.
- 探索K56对压力,焦虑,抑郁,睡眠和肠道微生物群的影响.
主要方法:
- 一个双盲,随机,安慰剂对照试验,涉及120名士和博士生.
- 干预使用Lacticaseibacillus paracasei K56 (6×10^10 CFU/d) 或安慰剂2周.
- 评估感知到的压力 (PSS-10),情绪 (DASS),睡眠,肠道微生物群和代谢物.
主要成果:
- 两组之间的感知压力 (PSS-10) 没有显著差异.
- 与安慰剂相比,K56补充剂显著降低了压力和焦虑症状 (DASS).
- 改善睡眠质量,提高血清素 (5-HT) 和调节肠道微生物群 (增加有益细菌,减少病原体) 被观察到与K56.
- 增加了黄油酸水平和乳酸菌丰富度和黄油酸之间的正相关性被注意到.
结论:
- 在研究生中,Lacticaseibacillus paracasei K56显示出减轻压力,减少焦虑和失眠的潜力.
- 肠道微生物组成和butanate代谢的K56诱导的变化可能是这些心理健康益处的基础.
更多相关视频
06:54A Virtual Simulation Experiment of Mechanics: Material Deformation and Failure Based on Scanning Electron Microscopy
Published on: January 20, 2023
07:43Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios
Published on: August 4, 2023
相关概念视频
Effects of Chemicals: Overview
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Drug Dependence
Effects of feedback
Feedback significantly modifies the gain of a control system. The gain of a system without feedback is altered by a factor of one plus GH, where G represents...
Agonism and Antagonism: Quantification
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
