设备特定感染的流行病学和对接受左心室辅助器件的患者的影响
Amit Iyengar1, Jason Feinman2, Joyce Jiang3
1Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
JHLT open
|March 27, 2025
概括
左心室辅助器具特定感染 (LSIs) 影响了超过三分之一的患者,通常是由葡萄球菌, Pseudomonas 和 Serratia引起的. 这些感染增加了住院治疗,但没有影响生存率.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 医疗器械 医疗器械
背景情况:
- 左心室辅助装置特定感染 (LSI) 是持久左心室辅助装置 (LVAD) 患者的重大并发症.
- 特定的传染病原体和相关的患者患病率对于LSIs已经被定义得很差.
- 这项研究评估了现代离心LVAD患者中LSI的发病率,流行病学和发病率.
研究的目的:
- 确定左心室辅助器件特定感染 (LSIs) 的发生率和流行病学.
- 在接受现代离心LVAD的患者中评估与LSI相关的发病率.
- 为了确定LSIs的预测因子和常见的致病生物.
主要方法:
- 从2015年1月到2021年3月,对使用HeartMate 3 LVAD植入物的成年患者进行了回顾性分析.
- 根据LSI的存在,根据培养阳性感染或干预需要定义的患者被分组.
- 分析了人口统计数据,培养结果和干预措施,在4年后审查了生存分析.
主要成果:
- 在206名LVAD接受者中,71人 (34.5%) 患有LSI.
- 主要的传染病原体包括葡萄球菌 (47.9%), Pseudomonas (15.5%) 和 Serratia (8.5%).
- 黑人种族和更高的体重指数是LSI的预测因素. 患有LSI的患者经历了额外的8天住院治疗.
结论:
- 在LVAD患者中,LSI是常见的,主要是由葡萄球菌, Pseudomonas 和 Serratia 引起的.
- 临床上伤害与重新住院的增加有关,但生存率并没有显著不同.
- 进一步的研究和预防策略对于改善LVAD患者护理至关重要.
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