肺移植前或之后的真菌殖民对存活率或慢性肺移植异位功能障碍的发展没有负面影响
Embla Bodén1,2,3, Fanny Sveréus1,2,3, Anna Niroomand1,2,3,4
1Department of Clinical Sciences, Lund University, 22184 Lund, Sweden.
JHLT open
|March 27, 2025
概括
在肺移植 (LTx) 之前或在移植后一年内发生的真菌殖民不会影响患者的生存率或慢性肺异位功能障碍 (CLAD). 这项研究发现,在LTx接受者中,与这些常见的真菌事件相关的风险没有增加.
科学领域:
- 移植免疫学 移植免疫学
- 传染病 传染病 传染病
- 肺部医学 肺部医学
背景情况:
- 肺移植 (LTx) 的生存受到慢性肺异位移植功能障碍 (CLAD) 和感染的挑战.
- 在第一年内,在LTx接受者中,真菌殖民和侵入性真菌感染 (IFI) 是常见的.
- 菌事件对CLAD和死亡率的影响仍在争论中.
研究的目的:
- 调查真菌殖民/IFI与LTx接受者的结局之间的关联.
- 确定移植前或移植后早期的真菌事件是否会影响存活率和CLAD发育.
主要方法:
- 对134名LTx受益人的回顾性分析 (2011-2020年).
- 随访时间中位数为3.9年.
- 在LTx后12个月内,根据国际共识定义的真菌殖民和IFI.
主要成果:
- 在101名患者中发生了真菌殖民;14名患者在12个月内发生了IFI.
- 61名患者有酵母 (例如,Candida spp.) 增长;56个在LTx之前被殖民.
- 菌殖民 (LTx前或后) 并没有显著影响存活率或CLAD.
结论:
- 在LTx后12个月内或之前的真菌殖民性与死亡率或CLAD的增加无关.
- 这些发现表明真菌殖民是常见的,但不会使LTx受体产生不良结果.
相关概念视频
Pulmonary Tuberculosis I
212
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
212
Tissue Transplantation
319
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
319


