心血管健康与肝功能标志物之间的关联:来自NHANES 2005-2018年的横截面研究
Huang Yu1, Tingyi Zhang1, Yankun Liu1
1Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Frontiers in medicine
|March 27, 2025
概括
改善心血管健康 (CVH) 与更好的肝功能标志物有关,包括较低的肝酶和较高的白蛋白. 影响这种关联的关键因素是尼古丁暴露,BMI和血液脂质.
科学领域:
- 心血管健康的心血管健康
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 心血管健康 (CVH) 与全身性疾病有关,但其与肝功能标志物的关联尚不清楚.
- 生活必需品8 (LE8) 是评估CVH的一个关键指标.
- 这项研究调查了LE8和普通人群中的肝功能之间的关系.
研究的目的:
- 研究用LE8测量CVH与肝功能标志物之间的关联.
- 确定导致CVH与肝功能之间关系的因素.
- 探索综合预防策略的潜在目标.
主要方法:
- 来自NHANES (2005-2018) 的21,156名美国成年人 (年龄≥20岁) 的数据分析.
- 评估肝功能标志物:ALT,AST,GGT,ALP,白蛋白,以及AST/ALT比率.
- 应用线性回归,受限立方线 (RCS),加权量子素和 (WQS) 和量子素g计算 (QGC) 分析.
主要成果:
- 较高的CVH得分与肝酶 (ALT,AST,GGT,ALP) 的降低以及白蛋白和AST/ALT比率的增加相关.
- 在CVH得分和ALT,ALP和AST/ALT比率之间观察到非线性剂量反应关系.
- 尼古丁暴露,BMI和血液脂质被确定为CVH-肝功能关联的重要贡献者.
结论:
- 在美国成年人中,CVH和肝功能标志物之间存在强烈的关联.
- 保持最佳的CVH可能有利于肝功能.
- 尼古丁暴露,BMI和血液脂质是通过CVH影响肝脏健康的关键可修改因素.
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