多基因风险和家庭过程之间的相互作用,用于预测青少年外化行为轨迹
Jinni Su1, Belal Jamil1, Kit K Elam2
1Department of Psychology, Arizona State University, Tempe, AZ, United States.
Frontiers in psychiatry
|March 27, 2025
概括
成人和儿童外部化行为的多基因分数预测了儿童外部化轨迹. 家庭冲突是一个关键的调解者,强调需要多样化,基因知情的研究和针对家庭过程的干预措施.
科学领域:
- 发展心理学 发展心理学
- 行为遗传学 行为遗传学
- 心理病理学 心理病理学
背景情况:
- 对于成人和儿童精神病理学研究中的多基因分数 (PGS) 如何预测童年特征的理解有限.
- 需要一种发展性方法来检查PGS和家庭过程在预测外部化行为方面的相互作用.
研究的目的:
- 检查成人和儿童的PGS与家庭过程之间的相互作用.
- 预测从童年后期到青春期早期的外部化行为轨迹在不同的年轻人中.
主要方法:
- 利用了青少年大脑认知发展 (ABCD) 研究的数据,包括种族和种族多样化的年轻人 (N=9,720).
- 收集了父母报告的外部化行为和年轻人报告的四年来育儿/家庭环境数据.
- 对年轻人样本进行基因定型,以获得多基因分数.
主要成果:
- 成人和儿童外化PGS都预测了更高的外化行为轨迹.
- 在非西班牙裔白人青年中,PGS预测家庭冲突增加,这反过来预测了更高的外部化行为.
结论:
- 基于成人和儿童的PGS对外化行为是有价值的预测指标,表明遗传影响的发展连续性.
- 家庭过程,特别是冲突,显著影响了青少年在不同群体的外部化行为.
- 调查结果强调了对不同人群进行研究的重要性,并在干预中针对家庭冲突的重要性.
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