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在COVID-19后长达24个月的感染后症状:德国柏林的一项匹配的队列研究
Anne Meierkord1,2, Daniel Schulze3, Maximilian Gertler1
1Institute of International Health, Charité Center for Global Health, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Frontiers in public health
|March 27, 2025
概括
长期COVID症状影响了42.9%的轻度COVID-19幸存者长达24个月. 许多症状在6.5个月内消失,但有些症状,如味觉/嗅觉丧失,持续时间更长.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 轻度的COVID-19 (冠状病毒疾病2019) 对健康的长期影响尚不清楚.
- 估计COVID-19后症状的患病率和时间进程对于患者护理和公共卫生战略至关重要.
研究的目的:
- 为了估计轻度COVID-19后的长期健康后果的患病率.
- 描述SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 感染后最多24个月的症状和症状的时间进程.
主要方法:
- 进行了一项匹配的队列研究,包括576名前COVID-19患者和302名未感染的个人.
- 参与者在测试后长达24个月内填写了一份回顾性月度症状问卷.
主要成果:
- 42.9%的前COVID-19患者报告了与长期COVID相容的症状,而未感染组的症状为21.2%.
- 味觉/嗅觉障碍,记忆障碍和呼吸短促在COVID-19幸存者中最常见.
- 症状通常在平均6.5个月内消失,尽管味觉/嗅觉和认知问题持续了更长时间. 住院,症状感染,低收入和女性性别是相关因素.
结论:
- 轻度病例中的COVID-19后症状通常在六个月内消失,但可能持续更长时间.
- 很大比例的未感染者也报告了长期的COVID相容症状,这表明可能有错误分类的可能性.
- 目前对长期COVID的定义可能需要修订,以提高诊断准确性和流行率估计.
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