在儿科中,PROMIS疲劳得分与心力衰竭严重程度有中度的相关性
Lindsay J May1, Josef Stehlik2, Zhining Ou2
1Department of Pediatrics, University of Utah, Salt Lake City, Utah.
JHLT open
|March 27, 2025
概括
患者报告结果测量信息系统 (PROMIS) 儿科疲劳得分与儿童心力衰竭 (HF) 严重程度有中等相关性. 这一发现表明,PROMIS疲劳可以帮助监测儿科HF患者和临床试验.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 临床结果研究研究
- 患者报告的结果
背景情况:
- 患者报告的结果测量 (PROMs) 在成人心力衰竭 (HF) 中很有价值,但在儿科HF中没有充分研究.
- 关于PROMs用于评估儿科HF严重程度的有效性存在有限的数据.
研究的目的:
- 评估患者报告结果测量信息系统 (PROMIS) 儿科疲劳得分和儿童心力衰竭 (HF) 严重程度之间的相关性.
- 评估PROMIS措施作为儿科HF护理中的辅助工具的有用性.
主要方法:
- 预计将在4家医院招收41名患有住院HF的儿童 (8-17岁).
- 在住院和门诊期间使用PROMIS测量 (包括疲劳) 和纽约大学儿科心力衰竭指数 (NYU PHFI).
- 使用配对t测试和混合效应模型进行统计分析以确定相关性.
主要成果:
- PROMIS儿科疲劳得分与HF严重程度 (r=0.5) 有中度的相关性,表明疲劳和疾病状态之间存在关联.
- 随着时间的推移,观察到PROMIS疲劳得分 (p=0.007) 和纽约大学PHFI得分 (p<0.001) 的显著改善.
- 在其他PROMIS措施中,除了同行关系外,还注意到了临床上有意义的改善.
结论:
- PROMIS儿科疲劳得分与儿童的HF严重程度有中等的相关性.
- 诺言疲劳是一种潜在的有价值的工具,用于长距离监测和临床试验在儿科HF.
- 普罗米斯的措施可以提高儿科心力衰竭的临床护理和研究.
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