2015年日本因感染而导致的癌症负担
Yingsong Lin1, Chaochen Wang1, Shogo Kikuchi1
1Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.
GHM open
|March 27, 2025
概括
像H. pylori和HBV/HCV这样的传染病原体在2015年导致了日本16.6%的癌症病例. 针对这些感染可以通过预防和根除策略显著减少癌症负担.
科学领域:
- 传染病流行病学 传染病流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 人口归因分数 (PAF) 量化了由病因因素引起的疾病负担.
- 了解与感染有关的癌症负担对于日本的公共卫生战略至关重要.
研究的目的:
- 估计2015年日本因特定传染病原体导致的癌症发病率和死亡率的人口可归因分数 (PAF).
- 确定导致日本人口癌症负担的最重要的传染病原体.
主要方法:
- 通过使用流行率和风险结果数据,估计了传染病原体 (H. pylori,HBV/HCV,HPV,EBV,HTLV-1) 的PAF.
- 假设癌症发展的潜伏期为10年.
- 分析了2015年日本人口的癌症发病率和死亡率数据.
主要成果:
- 2015年日本所有癌症病例中,传染病原体占16.6%.
- 男性的PAF比女性 (14.7%) 高 (18.1%).
- 杆菌 (H. pylori) 感染对癌症死亡的贡献最大,其次是乙型肝炎和型肝炎 (HBV/HCV) 和人类乳头瘤病毒 (HPV) 感染.
结论:
- 在日本,H. pylori和HBV/HCV仍然是导致癌症负担的最重要的传染病原体.
- 根除感染和接种疫苗等干预措施对于减少与感染有关的癌症至关重要.
- 公共卫生倡议应专注于预防和控制关键传染病原体,以降低癌症发病率和死亡率.
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