对于心室辅助器件的多中心结局,支持 II 阶段息失败的心室辅助器件
Edon J Rabinowitz1,2, Mary Mehegan2, Anna Joong3
1Division of Pediatric Critical Care Medicine, Washington University in St Louis, St Louis, Missouri.
JHLT open
|March 27, 2025
概括
系统性心室辅助器件 (SVAD) 在失败的第二阶段息 (S2P) 中的使用显示出有希望的生存率,尽管经常出现并发症. 需要进一步的研究来优化这些复杂的儿科患者的SVAD策略.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 机械循环支持 机械循环支持
- 遗传性心脏病是一种先天性心脏病.
背景情况:
- 第二阶段息 (S2P) 是单心室生理学复杂的手术程序.
- S2P的失败往往需要先进的干预措施,如心室辅助装置 (VAD).
- 关于在S2P失败的患者中使用VAD的结果的数据有限.
研究的目的:
- 评估S2P失败后患者的全身VAD (SVAD) 的临床过程,并发症和存活率.
- 为了确定与这一群体中不良事件和死亡率相关的因素.
主要方法:
- 多中心对先进心脏疗法改善结果网络注册表的回顾性审查.
- 分析了从2012年至2022年间植入SVAD的34名患者的数据.
- 评估植入前特征,装置策略,不良事件和生存结果.
主要成果:
- 该研究确定了34名患者,平均年龄为1.8岁,在S2P后需要SVAD支持.
- 常见的不良事件包括感染 (47%),中风 (29%) 和出血 (26%).
- 移植或恢复后的存活率为76%,移植后一年的存活率为56%.
结论:
- 在失败的S2P中,SVAD支持显示了令人鼓舞的临床结果,尽管不良事件的发生率很高.
- 设备策略中存在中心变化,突出了需要进一步研究的需要.
- 多机构合作对于优化这种患者群体的SVAD支持策略至关重要.
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