使用临床连续流量产生脉冲性流量
Joav Birjiniuk1, Deane E Smith2, Eugene A Grossi2
1Department of Surgery, New York University Langone Medical Center, New York, New York.
JHLT open
|March 27, 2025
概括
从连续流装置生成脉动流是具有挑战性的,因为粘性效应. 需要新的正位移来创造生理脉动的流动,并提高机械循环支的安全性.
科学领域:
- 生物医学工程 生物医学工程
- 心血管生理学心血管生理学
背景情况:
- 机械循环支持 (MCS) 越来越多地用于长期心肺功能增强.
- 目前的MCS设备面临的风险包括血栓形成,故障,不充分的心室卸载,右侧功能障碍和末端器官输液.
- 通过模仿自然生理流和压力概况来减轻这些风险,建议产生脉动流.
研究的目的:
- 用连续流装置来描述产生脉冲流的努力.
- 提出关于实现生理脉动流的挑战的机械论点.
- 突出需要新的脉动式设计的需要.
主要方法:
- 审查先前的文献和教科书,以建立理论基础.
- 分析与为脉动性修改连续流装置相关的机械挑战.
主要成果:
- 从连续流装置中创建脉动流的尝试受到振荡系统中粘性效应的阻碍.
- 现有的设备和研究设置无法产生真正的生理脉动流.
- 需要使用正位移的新设备来模仿本地心脏波形.
结论:
- 通过连续流装置产生脉动流的机械挑战限制了临床采用.
- 开发新的脉动性对于实现足够的生理脉动性至关重要.
- 改进的脉动式可以在机械循环支持中导致更好的副作用.
相关概念视频
01:29Gradually Varying Flow
Gradually varying flow (GVF) in open channels describes situations where water depth changes slowly along the channel due to factors like non-uniform bed slope, channel shape variations, or obstructions. This flow type occurs when the depth adjusts gradually to balance gravitational forces, shear forces, and energy requirements, resulting in a low rate of depth change.Characteristics of Gradually Varying FlowGVF is commonly observed in natural streams, rivers, and canals, where flow depth...
01:24Rapidly Varying Flow
Rapidly varying flow (RVF) in open channels is characterized by abrupt changes in flow depth over a short distance, with the rate of depth change relative to distance often approaching unity. These flows are inherently complex due to their transient and multi-dimensional nature, making exact analysis difficult. However, approximate solutions using simplified models provide valuable insights into their behavior.Key Features of Rapidly Varying FlowRVF is commonly observed in scenarios involving...