白质过敏症的种族和种族差异:血管风险因素的作用
Farooq Kamal1,2, Roqaie Moqadam2, Cassandra Morrison3
1Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
概括
在白质过敏症 (WMHs) 中存在种族和种族差异. 虽然血管风险因素解释了黑人个体的一些差异,但其他因素仍然存在,需要针对不同人群量身定制的方法.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 脑血管健康 脑血管健康
背景情况:
- 白质过敏症 (WMHs) 是与认知衰退相关的大脑血管疾病的指标.
- 现有的关于WMH负担的种族和民族差异的研究显示出不一致的结果.
- 这项研究调查了种族和种族对WMH负担的影响以及血管风险因素的作用.
研究的目的:
- 为了确定种族和民族是否影响白质高压负担.
- 确定血管风险因素是否调解了观察到的WMH的种族和种族差异.
- 探讨不同人群中WMH负担持续存在的差异.
主要方法:
- 使用了来自国家阿尔茨海默氏症协调中心 (NACC) 数据库的数据.
- 包括一个庞大的队列:7132名白人,892名黑人,283名亚裔和661名西班牙裔.
- 采用线性回归和混合效应模型来分析基线和纵向WMH,控制共变量.
主要成果:
- 调整血管风险因素显著减少了黑人和白人参与者之间的WMH负担差异.
- 在控制血管因素后,黑人和白人之间消除了部区域的WMH差异.
- 在西班牙裔个体的WMH差异仅在调整了血管风险因素后才变得具有统计意义.
结论:
- 血管风险因素部分解释了白质过敏症的种族和种族差异.
- 种族和民族之间持续存在的WMH差异强调了需要微妙的多维战略的需要.
- 研究结果强调了在管理WMH和认知衰退时考虑种族,种族和血管健康的重要性.
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