胸前动脉动脉瘤生长率和预测因素:系统性审查和元分析
Matthew Henry1, Carlos A Campello Jorge1, Pieter A J van Bakel2,3
1Department of Radiology University of Michigan Ann Arbor MI USA.
Journal of the American Heart Association
|March 27, 2025
概括
胸前动脉动脉瘤 (TAA) 的增长速度因原因而异,上升的TAA通常每年增长0.25-1毫米. 对大多数患者来说,每年监测可能过于频繁,并且缺乏生长预测因素.
科学领域:
- 心脏病学 心脏病学
- 血管外科 血管外科
- 遗传学 遗传学 是一个
背景情况:
- 胸前动脉动脉瘤 (TAA) 是一种严重的疾病,进展变化不定.
- 了解生长率 (GR) 和预测因素对于患者管理至关重要.
- 这项研究侧重于综合症,双主动脉和零星的TAA.
研究的目的:
- 系统地审查和元分析胸前动脉动脉瘤 (TAA) 的生长率 (GR).
- 为了确定TAA增长的潜在预测因素.
- 综合不同TAA病因学的证据.
主要方法:
- 发表的研究的系统审查和元分析.
- 搜索在线数据库,查找无症状TAA的成年患者.
- 综合症,双主动脉和零星TAA组的计算聚合GRs.
主要成果:
- 包括85项研究在综述中和55项在元分析中.
- 平均GRs有所不同:特纳综合征 (0.25毫米/年),马方综合征 (0.45毫米/年),洛伊斯-迪茨综合征 (0.81毫米/年).
- 双动脉TAA GR为手术前的0.37毫米/年和手术后的0.18毫米/年. 上升的零星TAAGR为0.33毫米/年,下降的TAAGR为2.71毫米/年.
结论:
- 上升的TAA通常在0.25-1毫米/年之间生长.
- 目前的年度监测频率可能过高,无法检测许多TAA病例的增长.
- 只有有限的高质量研究存在,TAA增长的预测因素仍然未被确定.
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