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Updated: May 20, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Published on: May 15, 2019

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强效和选择性的人类构成性安德罗斯坦受体激活器DL5055促进基于环胺的化疗

Dongdong Liang1, Linhao Li1, Yong Ai1

  • 1Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States.

Journal of medicinal chemistry
|March 27, 2025
PubMed
概括

开发出新的化合物来激活人类构成性安德罗斯坦受体 (hCAR),增强环胺 (CPA) 的代谢转化. 化合物DL5055显著提升了CPA.

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