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Updated: May 12, 2026

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各种消毒协议对内牙生物膜和从根性牙释放的生长因子的影响:一个体外研究

Abhilasha Gugliani¹, Sonali Taneja², Devi Charan Shetty³

¹Consultant Endodontist, ITS Centre for Dental Studies and Research, Uttar Pradesh, India.

European endodontic journal

|March 27, 2025

概括

素纳米颗粒和三重抗生素糊 (TAP) 在消除Enterococcus faecalis (E. faecalis) 生物膜和促进牙中的生长因子释放方面表现出卓越的有效性. 这些先进的消毒协议增强了根牙的愈合潜力.

科学领域:

牙周内科医院牙周内科医院牙周内科医院
微生物学微生物学
生物材料科学生物材料科学

背景情况:

根管中的细菌生物膜在内牙治疗中构成了重大挑战.
有效的消毒方案对于消除生物膜和促进牙再生至关重要.

研究的目的:

为了比较各种消毒方案对Enterococcus faecalis (E. faecalis) 生物膜的疗效.
评估这些协议对从根牙中释放生长因子 (TGF-β1和VEGF) 的影响.

主要方法:

提取的前被污染了E. faecalis生物膜.
样品仅用灌,氧化 (CH) 或三重抗生素糊 (TAP) 来处理.
最终的灌解决方案包括盐水,EDTA,植物酸和素纳米颗粒,随后进行CFU分析和ELISA用于增长因子量化.

主要成果:

三重抗生素糊 (TAP) 显示了最大的细菌减少,其次是CH和单独灌.
与其他最终灌剂相比,0.2%的奇托桑纳米颗粒显示出优异的生物膜减少和涂抹层去除.
素纳米颗粒和植物酸显著增加了TGF-β1和VEGF的释放.

结论:

0.2%的奇托桑纳米颗粒是高效的抗菌剂,具有出色的涂抹层去除能力.
TAP的放置是最佳的,以减少根通道中的细菌.
消毒协议显著影响生长因子的释放,TGF-β1的释放明显高于VEGF.

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