上腺激素激动剂口服脱血剂对血压的影响
Jocelyn Joy Chan1, Magnus Chan1, James M Wright1
1Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
The Cochrane database of systematic reviews
|March 27, 2025
概括
在长期使用时,上腺激动剂口服脱血剂对血压和心率几乎没有影响. 然而,证据非常不确定,由于理论风险,需要谨慎.
科学领域:
- 药理学 药理学是指药理学的学科.
- 心血管医学 心血管医学
- 系统审查是系统的审查.
背景情况:
- 上腺激素激动剂口服脱凝剂广泛用于鼻塞.
- 它们可能会增加血压是令人担忧的,但慢性影响尚未得到充分证实.
- 本次审查解决了缺乏对长期血压影响的全面评估的问题.
研究的目的:
- 评估上腺激素激动剂口服脱血剂对静缩和静缩血压的慢性影响.
- 评估对心率的影响和与不良事件相关的退出.
- 提供随机对照试验 (RCT) 的系统审查.
主要方法:
- 搜索了主要的数据库 (Cochrane,MEDLINE,Embase,ClinicalTrials.gov) 来查询到2024年7月的RCT.
- 包括至少为期七天的RCT,将口服降血剂与六岁以上个体的安慰剂进行比较.
- 使用固定效应模型分析数据,并使用GRADE评估证据确定性.
主要成果:
- 包括5个RCT,882名参与者,研究持续时间从1到24周.
- 上腺激素激动剂口服脱血剂对静脉血压 (确定性非常低) 和静脉血压 (确定性低) 几乎没有影响.
- 对心率的影响和由于不良影响而导致的退出也很小,证据的确定性非常低到很低.
结论:
- 慢性每日使用上腺激素激动剂口服脱血剂似乎对血压和心率的影响很小.
- 证据的确定性非常低,需要考虑理论风险.
- 需要进一步的独立,公正的试验来澄清这些影响.
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