芬兰肺高血压2008-2020年:描述性的现实世界队列研究 (FINPAH)
Markku Pentikäinen1, Piia Simonen1, Helena Tuunanen2
1Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
JHLT open
|March 27, 2025
概括
这项研究评估了芬兰的肺动脉高血压 (PAH) 和慢性血栓栓塞性肺高血压 (CTEPH),发现发病率和存活率与其他国家相似. 分析了患者的特征和风险因素,以提高对这些疾病的理解和治疗.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 肺动脉高血压 (PAH) 和慢性血栓栓塞性肺高血压 (CTEPH) 是影响肺动脉的严重疾病.
- 了解这些患者的特征,风险分布和预后对于有效管理至关重要.
研究的目的:
- 评估芬兰的PAH和CTEPH患者的人口结构,风险分层和生存结果.
- 将芬兰的数据与这些罕见疾病的国际发现进行比较.
主要方法:
- 对PAH和CTEPH患者的临床图表的回顾性审查,这些患者在2008年至2019年期间被诊断为PAH和CTEPH.
- 与国家死亡率数据的联系,以确定生存率和趋势.
主要成果:
- 该研究确定了627名患者,PAH的发病率为4.0/百万/年,CTEPH的发病率为2.9/百万/年.
- 患有PAH的患者 (n=268) 的平均年龄为57岁,73%为女性,异常性PAH是最常见的 (40%). 一,三,五年生存率分别为91.3%,74.8%和62.6%.
- CTEPH患者 (n=189) 的平均年龄为63,49%为女性. 1,3,5年生存率分别为94.6%,87.2%和79.4%,肺内关节切除术改善了结果.
结论:
- 芬兰的PAH和CTEPH患者的发病率和存活率与其他国家之前报告的数据一致.
- 影响PAH生存的关键因素包括亚型,心脏输出,以及诸如缺血性心脏病和2型糖尿病等并发症.
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