微量营养素通过中介大脑结构和功能对神经发育障碍的影响:双步门德尔随机化分析
Chanhua Li1, Jiatong Deng1, Weiyan Huang1
1Guangxi Medical University, China.
Autism : the international journal of research and practice
|March 27, 2025
概括
,和维生素B12显示出对自闭症,多动症和图雷特症的保护作用.
科学领域:
- 营养神经科学 营养神经科学
- 遗传流行病学遗传流行病学
- 神经发育障碍 神经发育障碍
背景情况:
- 微量营养素对神经发育至关重要,但它们在神经发育障碍中的作用仍在争论中.
- 自闭症谱系障碍 (ASD),注意力缺陷/多动症障碍 (ADHD) 和图雷特综合征 (TS) 是复杂的神经发育状况.
- 了解微量营养素与这些疾病之间的因果关系对于预防策略至关重要.
研究的目的:
- 研究关键微量营养素与ASD,ADHD和TS风险之间的关联.
- 探索大脑成像衍生的表型在这些协会中的调解作用.
- 为预防神经发育障碍的基于微量营养素的干预提供证据.
主要方法:
- 使用双样本的孟德尔随机化分析来评估遗传关联.
- 数据包括ASD (18,381),ADHD (38,691) 和TS (4,819) 的大量病例.
- 对脑成像衍生的表型 (n=33,224) 进行了调解效应分析.
主要成果:
- 含量增加与ASD风险降低有关 (OR 0.84).
- 增加的含量与较低的ADHD风险 (OR 0.92) 有关.
- 增加的维生素B12水平与TS风险降低相关 (OR 0.81).
- 调解分析显示,脑成像表型占这些影响的5.84%32.66%.
结论:
- 像,和维生素B12这样的微量营养素可能对特定的神经发育障碍有保护作用.
- 大脑结构和功能的改变部分介于这些保护性关联.
- 针对微量营养素缺乏症可能是预防神经发育障碍的可行策略,特别是在风险人群中.
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