在二双胞胎怀孕中,母亲和新生儿的结果:辅助生殖技术和自发受孕之间的比较
Gizem Berfin Uluutku Bulutlar1, Eralp Bulutlar2, Büşra Parlak Somuncu3
1Istanbul Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Istanbul, Türkiye. berfinuluutku@yahoo.com.
Ginekologia polska
|March 27, 2025
概括
辅助生殖技术 (ART) 双胞胎怀孕显示,母亲和新生儿的结果比自发受孕 (SC) 更糟糕. ART双胞胎面临更高的并发症风险,如早产,低出生体重和母亲的情况. 密集监测对于ART怀孕至关重要.
科学领域:
- 生殖医学 生殖医学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 新生儿结局的结果.
背景情况:
- 辅助生殖技术 (ART) 越来越多地用于怀孕.
- 双胞胎二二 (DCDA) 双胞胎占多胎妊娠的重要比例.
- 了解ART怀孕的DCDA双胞胎的结果对于临床管理至关重要.
研究的目的:
- 通过ART和自发受孕 (SC) 怀孕的DCDA双胞胎怀孕之间的母亲和新生儿结局进行比较.
- 为了确定与DCDA双胞胎的ART怀孕相关的特定不良结果.
主要方法:
- 对852例DCDA双胞胎怀孕的回顾性队列研究 (261例ART,591例SC).
- 从医院自动化系统中提取的数据.
- 统计分析包括千平方和曼特尔-汉泽尔测试,以控制混因子.
主要成果:
- 双胞胎ART怀孕的结果明显低于SC.
- 在ART组的风险增加: cerclage (12.6x),妊娠的肝内胆固醇 (19.2x),早产,出生时体重非常低,NICU入院,新生儿死亡.
- 在ART组中,妊娠糖尿病,妊娠引起的高血压,产后出血和剖腹产的发病率更高.
结论:
- 与自发受孕相比,人工智能受孕的DCDA双胞胎怀孕的母亲和新生儿的结果明显更差.
- 这些差异凸显了对ART双胞胎怀孕进行密集监测和量身定制的管理策略的需要.
- 需要进一步的研究来阐明导致这些不良结果的潜在机制.
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