怀孕期间的微量元素暴露对母婴二合体中围产期肠道微生物群有持久的影响
Yuqing Zhang1, Xu Yang2,3, Chao Dong2,3
1Department of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing 210004, China.
Environmental science & technology
|March 27, 2025
概括
母亲的微量元素暴露显著塑造了母亲和婴儿的肠道微生物群. 特定的元素,如,和影响微生物的组成和代际转移,影响婴儿的肠道健康.
科学领域:
- 微生物组研究的研究.
- 环境健康 环境健康
- 孕产妇与胎儿的医学
背景情况:
- 微量元素是已知的肠道微生物群修饰剂.
- 关于母体微量元素对肠道微生物群动态的影响以及对新生儿肠道微生物群的代际影响,人口数据有限.
研究的目的:
- 调查母亲对母婴肠道微生物群的微量元素暴露对母婴肠道微生物群的纵向影响.
- 确定影响母体和新生儿肠道微生物组成和相似性的特定微量元素.
主要方法:
- 纵向母婴双微生物群数据的分析.
- 母体血清微量元素水平与肠道微生物群概况的相关性.
- 检查对新生儿肠道微生物群的代际影响,特别是mconium Bifidobacterium.
主要成果:
- 母亲的微量元素暴露显著影响母婴肠道微生物群的组成和相似性.
- (Co), (Mo) 和 (Rb) 影响母体肠道微生物群的变化.
- 母亲 (Zn) 暴露和抗生素使用会影响母婴肠道微生物群的相似性.
- 卢比 (Rb) 显示出对麦科尼 (Bifidobacterium) 的代际影响,由传递方式和抗生素使用调节.
结论:
- 母亲的微量元素暴露对围产期肠道微生物群产生持久的影响.
- 这些发现为通过微量元素管理促进母亲和婴儿肠道健康提供了新的见解.
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