埃弗受体激活髓质检查点受体LILRB5,以支持瘤的发展
Yubo He1, Chengcheng Zhang1, Lingxiao Tan2
1The University of Texas Southwestern Medical Center, Dallas, TX, United States.
Cancer immunology research
|March 27, 2025
概括
某些Ef受体与白细胞Ig类受体家族B5 (LILRB5) 结合,这是一个髓质检查点受体. 这种相互作用促进免疫抑制性髓状细胞,阻碍抗癌免疫力和瘤发育.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 细胞信号传递 细胞信号传递
背景情况:
- 免疫抑制性髓状细胞阻碍了基于T细胞的癌症免疫疗法.
- 瘤细胞与髓状细胞相互作用以调节免疫反应的精确机制仍然不完全理解.
研究的目的:
- 为了研究瘤表达的Eph受体和髓质抑制受体之间的相互作用.
- 阐明白细胞Ig类受体家族B5 (LILRB5) 在调解瘤诱导的免疫抑制中的作用.
主要方法:
- 使用生物化学测试研究了Eph受体与LILRB5和LILRB2的结合.
- 在实验室中分析了癌症患者的髓状细胞中的LILRB5信号.
- 利用转基因小鼠与骨髓特异性LILRB5表达来研究瘤生长和免疫细胞群体体体内.
- 评估LILRB5阻断对Eph诱导信号和瘤进展的影响.
主要成果:
- 特定的Eph受体 (EphA7,EphB1) 与LILRB5和LILRB2.2结合在一起.
- 埃菲受体的参与激活了与LILRB5.5的双向信号传输.
- 在髓状细胞中的LILRB5激活促进免疫抑制标记物并减少激活标记物.
- 在小鼠中,骨髓细胞特异性LILRB5表达增强瘤生长,增加免疫抑制性骨髓细胞,并减少功能性T细胞.
- LILRB5阻断逆转了Eph诱导的免疫抑制和促进瘤的影响.
结论:
- 一些Eph受体与骨髓检查点受体LILRB5.5形成一个功能轴.
- 这种Eph-LILRB5相互作用驱动髓状细胞的免疫抑制,促进瘤的发展.
- 准Eph-LILRB5通路是增强抗癌免疫力的潜在策略.
相关概念视频
Mitogens and the Cell Cycle
6.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Receptor Downregulation in MVBs
2.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.0K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K


