21世纪与结肠镜相关的不良事件:更新的系统审查和元分析
Xiu-He Lv1,2, Qing Lu1,2, Zi-Jing Wang1,2
1Department of Gastroenterology and Hepatology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
这项研究分析了3850万次结肠镜检查,揭示了不良事件 (AE) 的关键率. 胃肠道出血是最常见的,而与结肠镜相关的死亡是罕见的,这凸显了持续改善安全的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 内镜手术 进行内镜手术
- 公共卫生 公共卫生
背景情况:
- 结肠镜检查是一种频繁的,通常风险较低的内镜检查.
- 与结肠镜检查相关的不良事件 (AE) 可能会带来临床挑战.
- 了解这些AE的全球发病率对于患者安全至关重要.
研究的目的:
- 估计结肠镜相关不良事件 (AE) 的全球发病率.
- 分析胃肠道和非胃肠道AE的频率.
- 通过子组分析,识别影响AE利率的潜在因素.
主要方法:
- 在多个数据库中系统地搜索基于人口的研究,直到2024年12月.
- 胃肠道和非胃肠道AE的元分析.
- 基于世卫组织地区,出版年份,样本规模,数据收集和研究设计的子组分析.
主要成果:
- 分析了82项研究,涉及3850万次结肠镜检查.
- 每10,000次结肠镜检查发生率:胃肠道的AEs (穿孔5.15,出血18.39,脏损伤0.61);非胃肠道的AEs (心血管的52.11,呼吸的4.26,死亡的0.18).
- 亚组分析显示了各种各样的发现;大多数研究都有低至中等的偏差风险.
结论:
- 这一元分析提供了关于全球结肠镜相关AE发病率的关键数据.
- 强调持续努力改善结肠镜检查安全的重要性.
- 为有针对性的风险减轻策略提供基础.
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