在一个D+患者中,反LW伪装成反D
Bushra Moiz1, Muhammad Hasan1, Muhammad Salman1
1Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
Immunohematology
|March 27, 2025
概括
一名老年男性产生了抗LW抗体,因B型淋巴增殖性疾病而使红细胞 (RBC) 输血复杂化. 使用特定红细胞单位的输血成功,解决了输血方面的挑战.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
背景情况:
- 兰德施泰纳-韦纳 (LW) 血型系统包括四种主要抗原:LWa,LWab,LWb和LWEM.
- 在怀孕或免疫失调期间,LW抗原表达可能会减少,可能导致抗LW抗体的形成.
研究的目的:
- 描述一个具有挑战性的红细胞 (RBC) 输血病例,该病例发生在一名具有抗LW抗体的老年男性身上.
- 在潜在的血液学疾病的背景下,调查抗LW抗体发展的原因.
主要方法:
- 血清检查包括抗体查和各种红细胞表型的反应性测试.
- 红血细胞的二甲利醇治疗以区分抗体特异性.
- 在LW血型系统的基因定型.
- 骨髓检查以诊断潜在疾病.
主要成果:
- 该患者呈现出抗LW抗体,导致与标准红细胞输血不相容.
- 抗体查揭示了特定的反应模式,包括通过dithiothreitol处理的细胞消除.
- 患者基因型确定证实LW*A/A (c.299A),表明LWa+b-表型.
- 被诊断出一种B型淋巴增殖性疾病.
- 用特定的A,D-RBC单位输血是成功的,没有意外.
结论:
- 弱化LW表达,可能是由于潜在的B-淋巴增殖性疾病,可能导致该患者产生抗LW抗体.
- 仔细选择兼容的红细胞单元,特别是A,D-单元,使得成功的输血支持.
- 这一案例凸显了对患有输血困难的患者进行彻底抗体检查的重要性.
关键词:
LWW LWW LWW LWW LWW LWW LWW LWW LWW兰德施泰纳维纳血型系统在Rh血型系统中,Rh血型是Rh.输血 输血 输血 输血 输血淋巴瘤淋巴瘤是什么没有霍奇金的非霍奇金更多相关视频
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