2024年抗癌治疗对骨的影响
Marie Teissonnière1, Mathieu Point2, Emmanuel Biver3
1Pharmacie, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Calcified tissue international
|March 27, 2025
概括
新的抗癌疗法,如向疗法和免疫疗法,可能会影响骨健康,增加骨折风险. 管理这些骨效应对于患者的生活质量和长期癌症缓解至关重要.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 最近癌症治疗的进展包括向疗法和免疫疗法,从而改善了患者的治疗结果.
- 骨健康并发症,如脆弱和骨折,是显著的长期副作用,影响患者的生活质量和自主权.
- 虽然荷尔蒙疗法对骨的影响已知,但新的向和免疫疗法对骨的影响需要全面审查.
研究的目的:
- 提供主要抗癌疗法与骨相关的副作用的全面审查.
- 分析与这些治疗相关的细胞效应,骨矿物质密度 (BMD) 变化和骨折发生率.
- 扩大审查范围,超越传统的激素疗法和葡萄糖皮质激素,包括新的药物.
主要方法:
- 对抗癌症疗法的文献综述,重点关注它们对骨健康的影响.
- 对各种药物类别的细胞机制,骨和骨折风险的数据分析.
- 综合针对性疗法,免疫疗法,激素疗法和葡萄糖皮质激素的信息.
主要成果:
- 针对性疗法和免疫疗法由于其多样化的机制和应用,在骨健康管理方面带来了新的挑战.
- 特定的药物类别对骨细胞,骨和骨折发生率有不同的影响.
- 葡萄糖皮质类药物和激素疗法虽然已经确立,但它们仍然是癌症患者骨健康的重要因素.
结论:
- 了解所有主要的抗癌疗法对骨的影响对于全面的患者护理至关重要.
- 骨健康的积极管理对于维持患者的生活质量和支持长期缓解至关重要.
- 需要进一步的研究,以充分阐明和减轻与新型癌症治疗相关的骨风险.
相关概念视频
01:29Bone Disorders
3.3K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.3K
02:49Cancer Therapies
7.4K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.4K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
01:31Osteoclasts in Bone Remodeling
2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
02:53Adaptive Mechanisms in Cancer Cells
5.5K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.5K
02:56Treatment Resistant Cancers
3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K