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Updated: May 8, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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纳维托克拉克斯在肝功能障碍中的药理动力学和安全性

Maulik Patel1, Jalaja Potluri2, Thomas Marbury3

  • 1Clinical Pharmacology, AbbVie Inc, South San Francisco, CA, USA.

Clinical pharmacokinetics
|March 27, 2025
PubMed
概括

这项研究发现,与正常肝功能患者相比,轻度至中度肝功能障碍患者的纳维托克拉克斯的药理动力学和安全性相似. 对于这些患有骨髓纤维化症的患者,不需要调整剂量.

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