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与IgG4相关的眼部疾病呈现为小儿病患者的后硬化炎
Irmak Karaca1,2, Albert John Bromeo1,3, Azadeh Mobasserian1
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, 2370 Watson Court, Palo Alto, CA, USA.
Journal of ophthalmic inflammation and infection
|March 27, 2025
概括
儿科IgG4相关的眼病 (IgG4-ROD) 最初可以呈现为后硬化症. 生物疗法,如infliximab,有效地管理炎症,并改善了患有这种疾病的儿童的结果.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 儿科 儿科 儿科
背景情况:
- 与IgG4相关的眼病 (IgG4-ROD) 是一种罕见的疾病,可以影响眼睛和眼道的各个部位.
- 后硬化,后的炎症,是IgG4-ROD的不太常见表现,特别是在儿科患者中.
研究的目的:
- 描述一名儿科病人的IgG4相关的眼病病例,表现为后硬化炎.
- 突出儿童IgG4-ROD的诊断挑战和治疗策略.
主要方法:
- 一个7岁的女孩出现了proptosis,眼皮胀和视力下降.
- 诊断工作包括光学连贯断层扫描,B扫描超声波,轨道MRI和实验室测试,包括血清IgG4水平.
- 治疗涉及最初的静脉注射甲基prednisolone,随后是口服普得尼松,甲状腺,并最终因疾病复发而导致infliximab.
主要成果:
- 患者表现出与后硬化和周围圈炎症相一致的症状.
- 血清IgG4水平升高证实了可能的IgG4-ROD的诊断.
- 使用因弗力西马布,甲和口服类固醇的联合治疗导致症状的消失和视力敏度的改善.
结论:
- 后硬化可能是IgG4-ROD在儿科患者的初始表现.
- 疾病的发展过程可能对初始治疗不耐药.
- 像Infliximab这样的生物药物对于长期控制IgG4-ROD中的炎症是有效的.
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