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Updated: May 5, 2026

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System
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d-氨基酸:新的功能洞察力

Loredano Pollegioni1, Natasa Kustrimovic1, Luciano Piubelli1

  • 1The Protein Factory 2.0 Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

The FEBS journal
|March 27, 2025
PubMed
概括

曾经被认为不自然的D-氨基酸 (d-AAs) 现在被认为是真核生物中的重要信号分子. 最近的研究强调了它们在健康和疾病中的多样性作用,包括作为潜在的生物标志物.

关键词:
d-阿斯巴酸盐的使用方法对于d-cysteine来说,这是一个很大的问题.它们是d-enantiomers的组成部分.这是一种d-serine.生物标志物 生物标志物信号传输 信号传输

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The hybridized nitrogen atom in amines possesses a lone pair of electrons and is bound to three substituents with a bond angle of around 108°, which is less than the tetrahedral angle of 109.5°. However, the C–N–H bond angle is slightly larger at 112°, with a carbon–nitrogen bond length of 147 pm. This carbon–nitrogen bond length of of amines is longer than the carbon–oxygen bond of alcohols (143 pm) but shorter than alkanes’...
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