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Updated: Jul 11, 2026

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing
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Published on: June 9, 2016

用于塑料压缩的生物模拟瘤模型的协议使用离心压缩.

Sam Devereaux1, Ashley Lam1, Anuja Upadhyay1

  • 1UCL Centre for 3D Models of Health and Disease, UCL Division of Surgery and Interventional Science, Faculty of Medical Sciences, Charles Bell House, University College London, 43-45 Foley Street, London W1W 7TY, UK.

STAR protocols
|March 27, 2025
PubMed
概括

我们开发了一种使用塑料压缩和离心法创建生物模拟瘤模型的新协议. 这种方法增强了原的密度和机械特性,以便更好地研究瘤微环境.

关键词:
癌症 癌症 癌症 癌症基于细胞的测试组织工程是组织工程.

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科学领域:

  • 生物医学工程 生物医学工程
  • 癌症研究 癌症研究
  • 生物材料科学 生物材料科学

背景情况:

  • 瘤微环境研究需要先进的模型.
  • 目前的瘤模型缺乏机械和结构复杂性.
  • 生物仿真工程为更准确的模型提供了一条道路.

研究的目的:

  • 提出一种用于工程生物模拟瘤模型的新方案.
  • 通过离心压缩利用塑料压缩来制造模型.
  • 为了增强瘤模型的机械性能和原密度.

主要方法:

  • 创建多部件瘤-肌瘤模型的协议.
  • 将细胞混合成一个在37°C时交联的原凝.
  • 液凝的离心,以创建分隔和分层模型.

主要成果:

  • 成功生成了分隔的瘤-肌瘤模型.
  • 封装一个96洞的瘤质量在一个24洞的肌体内.
  • 增加原蛋白密度和改善水凝的机械性能.

结论:

  • 该协议提供了一个强大的方法来设计先进的瘤模型.
  • 增强的机械特性改善了工程瘤模型的仿生学.
  • 这种技术有助于更准确的瘤生物学体外研究.