透皮牛皮的治疗灵感来自瘤微环境介导的免疫调节,并通过外体工程进步
Jieru Yang1, Jiaojiao Zhu1, Shan Lu1
1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China.
概括
研究人员重新利用瘤微环境策略来治疗牛皮. 黑色素瘤衍生外体通过调节T细胞通过特定的微RNA激活,有效地减少小鼠的牛皮病变,提供了一个新的治疗途径.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 纳米医学是一种纳米医学.
背景情况:
- 牛皮涉及异常的T细胞激活和表皮质增生,安全的透皮治疗有限.
- 瘤微环境具有免疫抑制机制,可以用于炎症性疾病.
研究的目的:
- 为了研究重新利用瘤衍生的免疫抑制策略用于牛皮治疗的潜力.
- 探索黑色素瘤衍生的外体在缓解牛皮病变中的治疗疗效.
主要方法:
- 在小鼠模型上局部应用非活化的黑色素瘤组织同质化物.
- 黑色素瘤衍生的外体的隔离和特征.
- 分析miRNA含量及其目标 (IL-17a).
- 开发一种仿生外体配方 (ExoLipo).
主要成果:
- 黑色素瘤衍生的外体在小鼠中减轻了牛皮病变.
- 外体细胞通过mmu-miR-320-3p和mmu-miR-126-5p调节IL-17信号,减少T细胞的激活.
- 富含RhoA蛋白质的外体增强了表皮屏障透细胞体.
- 埃克索利波 (ExoLipo) 显示出显著的预防和治疗效果,具有良好的安全性.
结论:
- 来自瘤的外基因组为牛皮提供了一个有前途的治疗策略.
- 重新利用瘤免疫抑制机制可以解决炎症性皮肤疾病.
- 埃克索利波 (ExoLipo) 是一种新的生物仿真方法,用于治疗透皮牛皮.
相关概念视频
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.