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Updated: May 11, 2026

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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
视力压力调节对正常压力眼内压力降低的负压的应用在正常压力眼内光眼中: HERCULES研究
Tanner J Ferguson1, Thomas W Samuelson2, Leon Herndon3
1From the Vance Thompson Vision (T.J.F., D.C.T., and J.P.B.), Sioux Falls, South Dakota, USA.
American journal of ophthalmology
|March 27, 2025
概括
眼睛压力调节有效降低正常压力玻璃眼 (NTG) 患者的眼内压力 (IOP). 这种新型设备在52周内显示出显著的内膜压力降低,没有严重的不良事件.
科学领域:
- 眼科医生 眼科 眼科
- 医疗器械 医疗器械
- 玻璃眼研究研究 玻璃眼研究
背景情况:
- 正常张力玻璃眼 (NTG) 具有视神经损伤和视野损失的特征,尽管眼内压力 (IOP) 处于正常范围内.
- 管理NTG通常涉及降低IOP以减缓疾病进展,但治疗选择可能是有限的.
研究的目的:
- 评估一种新型眼球压力调节的安全性和有效性,用于降低NTG患者的IOP.
- 使用该设备来评估白天和夜间的内血压降低.
主要方法:
- 一个前性的,多中心的,蒙面的,随机的,同伴眼睛的受控试验进行了.
- 纳入了NTG (IOP≥12 mm Hg和≤21 mm Hg) 的受试者,其中一只眼睛被随机选择接受来自的负压应用.
- 该设备在1年内穿着一晚,根据基线IOP编程负压.
主要成果:
- 在52周后,88.3%的研究眼睛实现了≥20%的白天IOP降低,而对照眼睛的比例为1.7%.
- 96.7%的研究眼睛实现了≥20%的夜间IOP降低,而对照眼睛的比例为5.0%.
- 平均夜间内膜压力降低8.0mmHg (39.1%),没有严重的不良事件报告;常见的副作用包括眼罩和眼周周围胀.
结论:
- 眼睛压力调节是一种安全有效的治疗方法,用于降低白天和夜间的眼睛压力在患有正常张力玻璃眼瘤的患者中.
- 该设备为管理NTG和防止进一步视力丧失提供了一个有前途的新疗法选择.
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