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Updated: May 6, 2026

Construction of Cell-based Neurotransmitter Fluorescent Engineered Reporters CNiFERs for Optical Detection of Neurotransmitters In Vivo
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一种新的选择性化酶9抑制剂,irsenontrine (E2027),增强神经元中的GluA1酸化,并通过循环GMP升高改善学习和记忆

Yasuharu Ishihara1, Mai Ando2, Yasuaki Goto2

  • 1Deep Human Biology Learning, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki, 300-2635, Japan; Laboratory of Genomics-based Drug Discovery, Doctoral Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, Degree Program in Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.

Neuropharmacology
|March 27, 2025
PubMed
概括

伊尔森氨酸是一种新型的固酶9抑制剂,通过增加循环GMP (cGMP) 水平来增强学习和记忆. 这表明它作为治疗阿尔茨海默氏症等疾病的认知功能障碍的潜在疗法.

关键词:
循环的良好生产规范 (GMP)情节性识别记忆 - 情节性识别记忆.在 GluA1 的情况下,GluA1爱尔森没有内脏.这是一种PDE9抑制剂.基化酶是一种基化酶.

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