记忆表现的个体间变化与记忆编码和检索期间的皮层-脑丘脑网络有关
Roberta Passiatore1,2, Antonella Lupo1, Nicola Sambuco1
1Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124 Bari, Italy.
概括
个人记忆性能与特定的大脑活动模式有关. 在中位 thalamus 的休息状态连接支持记忆,受编码和检索期间前部和中位 thalamus 激活的影响.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 神经成像是一种神经成像.
背景情况:
- 新记忆的编码涉及中间叶和前皮层之间的功能连接.
- 功能磁共振成像 (fMRI) 研究表明,在记忆编码之前和之后,这些连接发生了变化.
- 丘陵体可能会影响这些功能连接,不同的丘陵体核与不同的皮层网络相连.
研究的目的:
- 为了研究这种假设,在皮质 - thalamic招募变化影响个人记忆性能.
- 探索休息状态功能连接,记忆任务中的大脑活动和关联记忆性能之间的关系.
- 为了识别与记忆编码中个体间的变异性相关的明显的皮质 - thalamic模式.
主要方法:
- 采用多扫描fMRI协议,包括静止状态和关联记忆任务 (编码和检索阶段).
- 从两个独立的健康成年人样本 (N1=29,N2=108) 收集数据.
- 结构方程建模 (SEM) 用于分析皮质 - thalamic招募对记忆性能的直接和间接影响.
主要成果:
- 在前端双双体网络中,在前端双双体网络中中介性胸膜子划分的静止状态功能连接性和记忆性能之间发现了积极的关联 (R=0.270.36).
- 这种关系是由编码过程中前丘脑激活率下降和检索过程中中丘脑中部激活率增加的介导.
- 三个不同的个体群体在各个记忆阶段表现出不同的皮质 - thalamic模式,突出显示了个体间的变异性.
结论:
- 成功的关联记忆编码依赖于不同的皮质 - thalamic通路,特别是涉及中介性thalamic招募和前部子划分的抑制.
- 基线功能连接在中介性thalamic网络支持记忆性能通过前部和中介性thalamic激活模式的间接影响.
- 皮层-丘脑功能,特别是涉及前部和中部丘脑,是关联记忆编码的个人差异的基础.
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