药理疗法治疗胃衰竭的药理疗法
Michael Camilleri1, Kara J Jencks1
1Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
胃衰竭是一种运动障碍,导致恶心和延迟胃排空,有效的治疗方法有限. 本综述探讨了当前和需要的药理学策略来管理胃衰竭症状.
科学领域:
- 胃肠病学 胃肠病学
- 神经胃肠病学 神经胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃衰竭是一种神经胃肠道运动障碍,其特点是胃排空延迟,以及恶心,吐和腹痛等症状.
- 病理生理机制包括hypomotility,pylorospasm和内脏过敏.
- 常见的原因是异常,糖尿病和术后,其他因素包括药物和神经退行性疾病.
研究的目的:
- 审查胃衰竭的药理管理.
- 讨论 prokinetic 和 antiemetic 药物,针对 pylorus 的药物,以及神经调节器.
- 突出对有效的胃衰竭治疗的未满足需求,特别是对于耐火病例.
主要方法:
- 对用于胃衰竭管理的药理学药物的文献综述.
- 对药物类别的分析,包括 prokinetics,抗emetics,pyloric 剂和神经调节剂.
- 药物疗效的评估和当前的治疗环境.
主要成果:
- 目前用于胃衰竭的药理选择包括 prokinetic 和 antiemetic 药物.
- 梅托克洛普拉米德是FDA批准的唯一用于胃衰竭的药物.
- 对于更有效的治疗方法存在重大未满足的需求,特别是对于耐火性胃衰竭.
结论:
- 胃衰竭的药理管理涉及一系列的药物,但选择有限.
- 对于治疗胃衰竭的新型和更有效的药物有着至关重要的需求.
- 进一步研究胃衰竭病理生理学和药物开发是必不可少的.
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