儿科尾炎中多药耐药性病原体的增加:以色列南部长达十年的研究
Rimma Melamed1,2, Doreen Ozalvo1,3, Orli Sagi4
1Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
概括
儿童手术性尾炎的多药耐药 (MDR) 病原体从2010年至2020年显著增加,特别是在阿拉伯贝都因社区. 这一趋势需要更新抗生素管理计划和经验性治疗选择.
科学领域:
- 儿科手术 儿科手术
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 尾炎是儿童紧急腹部手术的主要原因.
- 静脉注射抗生素对于治疗外科尾炎并发症至关重要.
- 了解细菌病原体趋势对于有效的抗生素管理至关重要.
研究的目的:
- 分析细菌分布和抗菌素耐药性在儿科外科尾炎的趋势.
- 专门调查在两个民族群体中多药耐药 (MDR) 肠道细菌的兴起.
- 确定与增加MDR病原体患病率相关的人口因素.
主要方法:
- 2010-2020年间对患有手术性尾炎的儿童 (<18岁) 进行了观察性,单中心,回顾性研究.
- 在手术内进行的腹膜内细菌拭片培养的分析 (n=1,858).
- 单变量,多变量和时间序列分析以评估趋势和混因素.
主要成果:
- 在36.8%的病例中发现了致病细菌,通常是多微生物.
- 在阿拉伯贝都因社区 (32.6%) 和犹太社区 (18.6%) 中,耐多药 (MDR) 肠道细菌的流行率明显高于犹太社区 (18.6%).
- 观察到MDR病原体每年显著增加8.7%,主要是由年轻的儿童,男性和阿拉伯贝都因社区推动的.
结论:
- 儿科外科尾炎中MDR病原体的发生率在2010年至2020年间显著增加.
- 这种增长需要在实证抗生素选择和抗生素管理计划中仔细考虑.
- 社区特异性和与年龄相关的因素影响了MDR病原体在手术性尾炎的趋势.
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