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与COVID-19相关的心血管结果的性别差异:系统性审查和元分析
Tareq M Abubasheer1, Hanan M A Abubasheer2, Ramez M Odat3
1College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.
患有COVID-19的男性患心脏病,血栓,中风和死亡等严重心血管问题的风险更高. 这些发现强调了COVID-19心血管并发症中基于性别的显著差异.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在呼吸系统健康之外,COVID-19带来了重大风险,影响了心血管系统.
- 新出现的证据表明,COVID-19心血管并发症中可能存在基于性别的差异.
研究的目的:
- 系统地调查和量化COVID-19患者中各种心血管结果的基于性别的差异.
- 综合当前关于心肌梗塞,静脉血栓栓塞,中风,出血,心力衰竭和COVID-19后死亡率的性别差异的证据.
主要方法:
- 在PubMed/MEDLINE,SCOPUS和EMBASE进行了系统的文献搜索,截至2024年1月.
- 对11项确定的研究进行了元分析,其中包括31,044名男性和25,917名女性,使用Stata版本18.
主要成果:
- 男人表现出明显增加的风险静脉血栓栓塞事件 (RR: 1.43),严重出血 (RR: 1.22),中风 (RR: 1.46) 和死亡率 (RR: 1.21).
- 男人也表现出更高的体外膜氧化 (ECMO) 使用率 (RR: 2.14).
- 女性患心肌梗塞的风险略低 (RR:1.24),而心力衰竭和住院时间没有显著的性别差异.
结论:
- 被诊断为COVID-19的男性面临严重心血管并发症的风险要大得多,包括血栓事件,出血,中风和死亡率.
- 这些发现强调了性别和性别对COVID-19心血管后果的关键影响.
- 对性别特异性机制和量身定制的临床管理策略进行进一步的研究是有必要的.
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