对阿尔茨海默氏症的诊断模型的构建和评估,该模型基于与线粒相关的基因

Jiarui Liu1, Mengyu Yan2, Lihua Chen3

  • 1Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. liujiarui66666@163.com.

Scientific reports
|March 28, 2025
PubMed
概括

阿尔茨海默病 (AD) 与减少的线粒有关. 这项研究确定了AD诊断的关键菌相关基因 (YWHAZ,NDE1),并揭示了它们在基因调节和免疫细胞透中的作用.

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...