在子宫内暴露于甲基酸盐,安非他胺和阿托莫克赛丁以及后代神经发育障碍 - 一项基于人口的队列研究和元分析
Kathrine Bang Madsen1,2,3, Henrik Larsson4,5, Charlotte Skoglund6,7
1Department of Clinical Research, University of Southern Denmark, Odense, Denmark. kbmadsen@health.sdu.dk.
Molecular psychiatry
|March 28, 2025
概括
在子宫内接触注意力缺陷/多动障碍 (ADHD) 药物,如甲基酸盐,安非他胺和阿托莫克赛丁,不会增加儿童神经发育障碍的风险. 这项大规模的研究为孕妇和医疗保健提供者提供了关键的安全数据.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 药理学 药理学是指药理学的学科.
背景情况:
- 怀孕期间越来越多地使用ADHD药物引起了人们对后代神经发育的潜在长期影响的担忧.
- 关于产前接触ADHD药物的安全性现有的数据是有限的,特别是对于像阿托莫克赛丁和安非他胺这样的新疗法.
研究的目的:
- 调查子宫内接触甲基酸盐,安非他胺和阿托莫克赛丁与后代神经发育障碍 (NDD) 风险之间的关联.
- 提供强有力的证据,为使用ADHD药物的孕妇提供临床指南和决策.
主要方法:
- 一项基于人口的队列研究,利用瑞典登记册,包括2008-2017年间出生的861,650名儿童.
- 暴露被分类为怀孕期间赎回的药物;结果包括任何NDD,ADHD和自闭症谱系障碍 (ASD).
- 统计分析包括考克斯比例危险回归,灵敏度分析 (药物类型,时间,持续时间,兄弟姐妹比较) 和与丹麦研究进行的元分析.
主要成果:
- 在子宫内暴露的儿童中,没有观察到任何NDD (aHR 0.95),ADHD (aHR 0.92) 或ASD (aHR 0.86) 的统计学意义上的风险增加.
- 敏感性分析和元分析始终支持在各种暴露场景中没有增加NDD风险.
- 这项研究复制并扩展了甲基酸,安非他胺和阿托莫克赛丁在产前暴露方面的安全数据.
结论:
- 在子宫内接触常见的ADHD药物并没有增加后代长期神经发育障碍的风险.
- 研究结果支持在临床上表明时,在怀孕期间安全使用这些药物.
- 这项研究为医疗保健提供者和孕妇提供了关键证据,使他们能够做出明智的治疗决定.
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