在精神疾病的脑刺激中,个性化的四个维度是:背景,目标,剂量和时间
Ghazaleh Soleimani1,2, Michael A Nitsche3,4,5, Colleen A Hanlon6,7
1Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA. solei039@umn.edu.
概括
个性化非侵入性脑刺激 (NIBS) 通过根据个体患者的因素量身定制跨电 (tES) 和磁性 (TMS) 刺激方案,可以提高精神疾病的治疗疗效.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物医学工程 生物医学工程
背景情况:
- 非侵入性大脑刺激 (NIBS) 显示出治疗精神疾病的前景.
- 经FDA批准的用于抑郁症,强迫症和尼古丁使用障碍的跨磁刺激 (TMS) 证明了有效性.
- 治疗反应的个体变化需要个性化的方法.
研究的目的:
- 讨论个性化tES/TMS协议的维度.
- 提出一个多方面的方法来个性化NIBS.
- 通过精准医学提高精神疾病的治疗效果.
主要方法:
- 讨论tES/TMS的个性化策略.
- 提出一个四层次的方法:背景,目标,剂量和时间.
- 解决个人间和个人内部的变化.
主要成果:
- 个性化向,就像基于fMRI的方法一样,显示出更高的效果大小.
- 个性化解决了干预效应的变化.
- 鼓励对个性化NIBS采取系统的方法.
结论:
- 个性化NIBS为精神疾病提供了准确医学的途径.
- 个性化大脑刺激可以改善临床结果.
- 尽管面临挑战,但鼓励更广泛地采用个性化NIBS技术.
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