相关实验视频
Updated: May 11, 2026
13:10
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
Published on: March 10, 2020
循环RNA在人类疾病中的新兴作用和临床应用
Subhayan Sur1, Jayanta K Pal2, Soumya Shekhar3
1Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Tathawade, Pune, 411033, India. subhayan.sur@dpu.edu.in.
Functional & integrative genomics
|March 28, 2025
概括
循环RNAs (circRNAs),稳定的非编码RNAs,调节基因表达,并与疾病有关. 它们的独特结构使得它们成为各种人类疾病的有前途的诊断和治疗生物标志物.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 生物化学 生物化学
背景情况:
- 循环RNAs (circRNAs) 是一种非编码RNAs类,具有独特的共价封闭结构.
- 尽管 circRNAs 的数量众多,但只有很少一部分的 circRNAs 的功能已经得到了描述.
- 循环RNAs表现出高稳定性和细胞特异性表达,影响细胞过程.
研究的目的:
- 审查circRNAs在人类疾病中的生物发生,分子功能和临床潜力.
- 突出circRNAs作为诊断和治疗生物标志物.
- 讨论 circRNA 研究当前的证据,挑战和未来的方向.
主要方法:
- 关于circRNA研究的文献综述.
- 对circRNA生物发生和功能进行分析.
- 在疾病病原和临床应用中对circRNAs的评估.
主要成果:
- 循环RNA在基因转录,翻译和后翻译中发挥作用.
- 异常的circRNA表达与癌症,神经退行性,心血管疾病和糖尿病有关.
- 循环RNA显示出潜力作为体液中的稳定生物标志物,用于疾病诊断和治疗.
结论:
- 循环RNA是基因表达的关键调节者,在人类疾病中起着重要作用.
- 它们的稳定性和特异性使它们成为有价值的诊断和治疗目标.
- 进一步的研究是必要的,以充分利用circRNAs在医学中的翻译潜力.
相关概念视频
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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
01:23RNA Interference
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
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02:39lncRNA - Long Non-coding RNAs
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02:15Experimental RNAi
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01:26Human Virome
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