由Streptococcus sinensis引起的传染性内心炎,诊断为下一代测序:一个病例报告和文献综述
Rong Wang1,2, Bin Niu1,2, Jiaolong Ren1
1Department of infectious Diseases, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030000, China.
BMC infectious diseases
|March 28, 2025
概括
下一代元基因组测序 (mNGS) 有助于诊断罕见的传染性内心炎 (IE) 病例,特别是当标准方法失败时. 这种先进的技术,加上向性抗生素,改善了在具有挑战性的感染患者的结果.
科学领域:
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
- 心脏病学 心脏病学
背景情况:
- 由Streptococcus sinensis引起的传染性内心炎 (IE) 是罕见的,难以诊断的.
- 传统方法经常失败,特别是在血液培养负内心炎 (BCNE) 中.
- 下一代元基因组测序 (mNGS) 为识别难以捉摸的病原体提供了更高的准确性.
研究的目的:
- 突出mNGS在具有挑战性的IE案例中的诊断实用性.
- 审查关于Streptococcus sinensis引起的IE的现有文献.
- 强调mNGS在诊断IE中的补充作用.
主要方法:
- 一个33岁的男性患有长期发烧和疑似IE的病例报告.
- 诊断工作包括血培养,心声学和血液/组织mNGS.
- 对11个额外的S. sinensis IE病例进行文献审查.
主要成果:
- 血液和膜组织的mNGS确定了Streptococcus sinensis作为致病剂.
- 文献审查揭示了与牙科手术和常见治疗方案的关联.
- 大多数患者需要手术干预,报告的结果良好.
结论:
- mNGS对于诊断IE至关重要,当标准方法无法确定时,特别是使用抗生素后.
- mNGS是补充,但不取代传统的微生物学技术.
- 将mNGS纳入临床实践可以改善IE诊断和治疗策略.
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