下丘脑雌激素受体α通路参与了高强度间歇训练诱导的绝经前老鼠内脏脂肪损失
Juanjuan Wang1,2, Shuai Tian1, Jinchan Du1
1School of Physical Education, Hebei Normal University, Shijiazhuang, China.
Lipids in health and disease
|March 28, 2025
概括
高强度间歇训练 (HIT) 通过在恢复期间激活下丘脑雌激素受体α (ERα) 途径,增强能量消耗和脂肪损失,有效地减少绝经前女性的内脏脂肪组织 (VAT).
科学领域:
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
- 代谢健康 代谢健康
背景情况:
- 内脏脂肪组织 (VAT) 积累与代谢疾病有关.
- 高强度间歇训练 (HIT) 和中等强度训练 (MIT) 均可降低VAT,HIT对女性的有效性更大.
- 雌激素受体α (ERα) 途径是运动诱导的代谢变化的潜在媒介.
研究的目的:
- 调查下丘脑ERα在调解HIT和MIT引起的增值税损失中的作用.
- 为了检查这些运动方式对前后绝经前后雌性老鼠模型中下丘脑电生理学和体内代谢的影响.
- 为了确认下丘脑ERα通路参与运动诱导的变化.
主要方法:
- 通过卵巢切除或假手术建立了绝经前和绝经后的雌性老鼠模型.
- 长期,距离匹配的HIT和MIT干预措施.
- 评估ERα表达,食物摄入,自发体力活动 (SPA),VAT质量/形态,下丘脑局部场潜力 (LFPs) 和运动后过度氧耗 (EPOC).
- 在运动后恢复期间,下丘脑ERα通路的化学阻塞.
主要成果:
- 在绝经前,但不是绝经后的老鼠中,HIT增加了下丘脑ERα表达,与增强的α和β频段LFP功率相关.
- 与MIT相比,HIT导致更大的增值税损失,更高的EPOC和更高的代谢作用,与绝经前老鼠相比,HIT导致更大的增值税损失,更高的EPOC和更高的代谢作用.
- 化学封锁ERα取消了由HIT引起的EPOC升高和增值税催化.
结论:
- 低垂体ERα通路对于在绝经前雌性大鼠的运动后恢复期中调解HIT诱导的EPOC升高和增值税降低至关重要.
- 这些发现强调了一种特定的机制,即运动会影响女性的身体组成和代谢健康.
更多相关视频
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
11.7K
06:28A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
2.1K
相关概念视频
01:40Hormonal Regulation
37.7K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
37.7K
01:33Hormonal Regulation
30.5K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
30.5K
01:22Target Cell Response to Hormones
5.6K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
5.6K
01:29Cholesterol: Significance and Regulation
2.1K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
2.1K
01:22Hormonal Regulation of the Menstrual Cycle
2.4K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
2.4K
01:30Hormonal Control of the Ovarian Cycle
5.2K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
5.2K