在COVID-19大流行后的初级保健中,抗生素使用量增加
Sky Wei Chee Koh1,2, Si Hui Low1, Jun Cong Goh1
1National University Polyclinics, National University Health System, Singapore 119228, Singapore.
Antibiotics (Basel, Switzerland)
|March 28, 2025
概括
抗生素处方在流行后增加,特别是在呼吸道问题和呼吸道问题上.
科学领域:
- 初级保健研究研究初级保健研究
- 传染病流行病学 传染病流行病学
- 抗微生物药物管理委员会
背景情况:
- COVID-19 流行病对医疗保健产生了重大影响,可能会改变初级保健机构的感染模式和抗生素处方做法.
- 了解流行后抗生素利用趋势对于有效的抗菌药物管理和公共卫生至关重要.
- 放宽公共卫生措施可能会影响感染的呈现和随后的抗生素处方.
研究的目的:
- 调查COVID-19大流行后在初级保健中使用口服抗生素的趋势.
- 分析抗生素被处方的疾病类型,并使用世卫组织AWaRe分类来评估抗生素的质量.
- 评估抗生素处方率的变化,并确定这些变化的关键驱动因素.
主要方法:
- 这是一项多中心的回顾性队列研究,涉及新加坡西部七家公共初级保健诊所.
- 对2022年至2023年间口服抗生素处方的分析,通过NTI,DID和DDD计算每100次访问的使用量.
- 对每月处方的细分回归分析,以确定利用趋势和驱动因素.
主要成果:
- 抗生素处方率从2022年的3.5%增加到2023年的4.0%,相对增加了9.5%.
- 呼吸道疾病是主要的驱动因素,处方增加了68.3%,特别是上呼吸道感染.
- 2022年观察到"观察"组抗生素使用的显著增加,尽管整体NTI在2023年略有下降.
结论:
- 肺部疾病抗生素处方的流行后激增需要针对性的抗菌药物管理干预措施.
- "观察"组抗生素使用量的增加需要仔细监测和管理.
- 优化治疗和改进诊断编码是减少不必要的抗生素处方的重要策略.
更多相关视频
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
06:27Automated Hospital Room Disinfection Utilizing a Novel Aerosolized Hydrogen Peroxide Microdroplet Disbursing Technology
Published on: February 24, 2026
相关概念视频
00:57Antibiotic Selection
Overview
01:28Antimicrobial Effectiveness
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
01:30Development of Antibiotic Resistance
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
01:25Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...