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免疫检查点抑制剂和癌症成年人的认知:一个范围审查
Síofra Hearne1,2,3, Muireann McDonnell3, Amanda Hanora Lavan2,4
1School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland.
Cancers
|March 28, 2025
概括
癌症治疗可能会导致认知能力下降. 这次审查发现对免疫检查点抑制剂和认知问题的研究有限,特别是在老年人中,强调需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
背景情况:
- 与癌症相关的认知衰退会影响任何癌症阶段的成年人.
- 老年人面临着更高的认知能力下降的风险.
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗,需要了解它们的认知副作用.
研究的目的:
- 审查关于ICI和认知衰退 (主观/客观) 的现有文献.
- 为了确定特定于老年人的证据.
- 探索与年龄相关的差异,并确定研究差距.
主要方法:
- 使用四个主要的电子数据库进行了范围审查.
- 研究使用标准化方法进行了选.
- 包括专注于ICI治疗和认知功能评估的研究.
主要成果:
- 十项研究符合纳入标准.
- 六项研究使用客观认知评估;八项使用主观评估.
- 发现了方法和评估工具的差异;很少有研究报告了特定年龄的发现.
结论:
- 对ICI相关认知衰退的进一步研究有显著的需要.
- 标准化的方法和评估对于未来的研究至关重要.
- 老年人需要特别关注,因为他们的认知能力下降的风险增加.
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