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Updated: Jun 8, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening
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开发一个基于miRNA的模型来检测肺癌

Kai Chin Poh1, Toh Ming Ren1, Goh Liuh Ling2

  • 1Division of Respiratory Medicine, Sengkang General Hospital, Singapore 544886, Singapore.

Cancers
|March 28, 2025
PubMed
概括

这项研究表明,将血清microRNA (miRNA) 生物标志物与肺结节大小相结合,可显著提高肺癌检测准确度. 这种综合方法为增强当前肺癌查方案提供了一个有前途的工具.

关键词:
生物标志物 生物标志物低剂量计算机断层扫描.肺癌查 肺癌查 肺癌查这是一个小RNARNA.这是一个微型RNA.

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MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...