评估索拉费尼布 (SORA-2) 作为第二线治疗不可切除的肝细胞癌:欧洲回顾性多中心研究
Christian Möhring1,2, Moritz Berger3,4, Farsaneh Sadeghlar1
1Department of Medicine I, University Hospital of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
Cancers
|March 28, 2025
概括
晚期肝细胞癌 (HCC) 中二线索拉芬尼的治疗结果与肝功能良好患者的其他治疗方法相似. 需要进一步的研究来确定用于优化HCC治疗算法的响应预测因子.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 医学瘤学 医学瘤学
- 临床研究 临床研究
背景情况:
- 对不可切除的肝细胞癌 (HCC) 的系统治疗已经发展,免疫检查点抑制剂作为首选的第一线治疗.
- 选择最优的第二线 (2L) 治疗晚期HCC是具有挑战性的,因为多种药物和缺乏确定的序列.
- 索拉费尼布经常被用作2L治疗,但支持数据有限.
研究的目的:
- 评估索拉费尼布作为二线 (2L) 治疗不可切除的肝细胞癌 (HCC) 的有效性.
- 为了确定影响先进HCC患者在一线治疗失败后结果的因素.
- 评估索拉费尼布在高级HCC的2L环境中的作用.
主要方法:
- 来自12个欧洲中心的81名不可切除的HCC患者进行了回顾性多中心研究.
- 患者接受索拉费尼布作为二线治疗 (2L).
- 评估了总生存 (OS),无进展生存 (PFS),放射性反应和毒性;进行了单变量和多变量分析.
主要成果:
- 平均总生存时间 (mOS) 为7.4个月;平均无进展生存时间 (mPFS) 为3.7个月.
- 多变量分析确定了Child-Pugh A和AFP水平<400 ng/mL作为最佳中位 OS (15.5个月) 的预测指标.
- 3级以上的不良事件发生在59.4%的患者中.
结论:
- 在欧洲HCK患者中,二线索拉芬尼表现出与其他已确立的2L选项相似的结果,肝功能保持良好,表现良好.
- 这项研究提供了关于索拉费尼布在高级HCC的2L设置中的作用的真实数据.
- 进一步的研究至关重要,以确定反应和生存的预测因素,以优化HCC治疗算法.
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