相关实验视频
Updated: Jun 6, 2026

11:09
Chromatin Isolation by RNA Purification (ChIRP)
Published on: March 25, 2012
LncRNAs乘坐了表观遗传标记的风暴
Giulia Gaggi1,2, Clinton Hausman3,4,5, Soomin Cho3,4,5
1Department of Medicine and Aging Sciences, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Genes
|March 28, 2025
概括
长非编码RNAs (lncRNAs) 是基因表达和表观遗传学的关键调节者. 它们的失调有助于遗传疾病和癌症,提供潜在的治疗点.
科学领域:
- 基因组学就是基因组学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在细胞功能中的关键作用.
- lncRNAs的失调与各种疾病有关,包括癌症和遗传疾病.
- lncRNAs通过表观遗传机制显著影响基因表达.
研究的目的:
- 审查目前对 lncRNA介导表观遗传调节的理解.
- 突出 lncRNAs 在癌症和遗传疾病发展中的影响.
主要方法:
- 关于 lncRNA 研究近期进展的文献评论.
- 分析lncRNA在表观遗传修饰中的作用 (DNA甲基化,基因素修饰,染色质重塑).
主要成果:
- lncRNAs是控制细胞生长和发育的基因调节通路的组成部分.
- lncRNAs调节表观遗传景观,影响基因表达.
- 特定的lncRNAs与各种癌症和遗传疾病的发病有关.
结论:
- lncRNAs是重要的表观遗传调节器,具有重要的生物医学影响.
- 针对 lncRNAs 提供了癌症和遗传疾病的潜在治疗策略.
相关概念视频
Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Epigenetic Regulation
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...

