LGR4 (GPR48):骨免疫学的新兴桥梁
Wonbong Lim1,2,3,4
1Department of Orthopaedic Surgery, Chosun University, Gwangju 61453, Republic of Korea.
Biomedicines
|March 28, 2025
富含亮氨酸重复序列的G蛋白偶联受体4（LGR4）是G蛋白偶联受体（GPCR）家族成员，在骨疾病中多个分化阶段及多种靶点均参与多种调控功能。因此，LGR4可能是核因子-κB配体（RANKL）在破骨细胞分化过程中的潜在调控因子。然而，目前尚缺乏对其在骨免疫学中功能与应用的系统性研究。本文综述了LGR4的分子特征、信号通路及其在骨免疫学中的作用，特别聚焦于其在破骨细胞分化过程中与RANKL的相互作用，并指出了有待进一步研究的关键空白领域。
富含亮氨酸重复序列的G蛋白偶联受体4（LGR4）是G蛋白偶联受体（GPCR）家族成员，在骨疾病中多个分化阶段及多种靶点均参与多种调控功能。因此，LGR4可能是核因子-κB配体（RANKL）在破骨细胞分化过程中的潜在调控因子。然而，目前尚缺乏对其在骨免疫学中功能与应用的系统性研究。本文综述了LGR4的分子特征、信号通路及其在骨免疫学中的作用，特别聚焦于其在破骨细胞分化过程中与RANKL的相互作用，并指出了有待进一步研究的关键空白领域。
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