在精神分裂症中,功能层次结构的改变半球不对称性
Yi Zhen1,2, Hongwei Zheng3, Yi Zheng1,2
1School of Mathematical Sciences, Beihang University, Beijing 100191, China.
Brain sciences
|March 28, 2025
概括
精神分裂症改变了大脑的功能层次结构,在关键网络中显示出异常的半球不对称性. 这些大脑差异可以区分患者和健康个体,并预测症状严重程度.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症是一种严重的精神疾病,影响知觉和认知.
- 以前的研究表明精神分裂症的皮质形态异常和功能连接性异常.
- 精神分裂症对功能连接体层次结构中的半球不对称的影响仍然不清楚.
研究的目的:
- 研究半球不对称性在精神分裂症中功能连接体的等级组织.
- 分析精神分裂症患者和健康对照者之间的功能梯度不对称的差异.
主要方法:
- 将梯度映射框架应用于半球功能连接组.
- 估计了三个关键的功能梯度,代表了层次组织.
- 评估了这些梯度之间的半球内和半球间的不对称性.
主要成果:
- 精神分裂症患者在注意力,视觉和控制网络的功能梯度中显示出显著改变的半球不对称性.
- 在特定的皮质区域发现了异常的梯度不对称性,包括前额和体运动区域.
- 半球梯度不对称性使患者与对照区分开来,并预测了积极的症状严重程度.
结论:
- 精神分裂症与大脑功能层次结构中半球不对称的改变有关.
- 这些发现为精神分裂症中不典型的大脑侧向化提供了新的见解.
- 功能梯度不对称可能成为精神分裂症的潜在生物标志物.
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