双极性障碍,线粒体功能障碍和反应性氧物种之间的关联
Yuki Kageyama1, Shohei Okura1, Ayaka Sukigara1
1Department of Neuropsychiatry, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan.
Biomolecules
|March 28, 2025
概括
线粒体功能障碍和氧化压力与双相情感障碍 (BD) 有关. 本综述探讨了线粒体缺陷如何产生反应性氧物种 (ROS),为BD病理生理学做出贡献,并提出了新的治疗点.
科学领域:
- 细胞生物学 细胞生物学
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 线粒体对于通过氧化酸化来产生细胞能量至关重要.
- 除了能量之外,线粒体还调节,亡,信号传递,新陈代谢和活性氧物种 (ROS).
- 线粒体功能障碍越来越多地与双极性障碍 (BD) 的病理生理学有关.
研究的目的:
- 审查线粒体功能障碍和双相情感障碍 (BD) 之间的联系.
- 探索线粒体缺陷如何促进BD中的活性氧物种 (ROS) 生产和氧化应激.
- 为了确定针对BD治疗的线粒体功能的潜在治疗策略.
主要方法:
- 文献综述专注于BD中的线粒体功能障碍.
- 分析将线粒体缺陷与ROS生成和氧化应激联系起来的机制.
- 检查信号传递,能量代谢和线粒体功能障碍的质量控制.
- 讨论在BD患者中观察到的特定线粒体异常.
主要成果:
- 线粒体功能障碍通过过度的ROS产生导致氧化应激.
- ROS可以损害神经元组件,损害神经传递和影响情绪调节.
- 能量代谢,ROS管理和线粒体的缺陷加剧了线粒体功能障碍.
- 异常的信号传递也可能导致线粒体功能障碍.
结论:
- 线粒体功能障碍和相关的氧化应激是BD病理生理学的关键因素.
- 准线粒体功能和减少ROS可能为BD提供新的治疗途径.
- 对BD中线粒体机制的进一步研究对于开发有效的治疗方法至关重要.
相关概念视频
01:37Mitochondria
13.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.5K
01:45Mitochondrial Membranes
11.7K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
11.7K
01:46Electron Transport Chain: Complex I and II
11.9K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
11.9K
01:41The Supercomplexes in the Crista Membrane
2.3K
The mitochondrial cristae membrane is the primary site for the oxidative phosphorylation (OXPHOS) process of energy conversion mediated through respiratory complexes I to V. These complexes have been widely studied for decades, and it has been proven that they form supramolecular structures called respiratory supercomplexes (SC). These higher-order complexes may be crucial in maintaining the biochemical structure and improving the physiological activity of the individual complexes while...
2.3K
01:24Peroxisomes
13.6K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
13.6K
01:30Bipolar Disorder
1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K