相关实验视频
Updated: May 13, 2026

08:10
Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
Published on: April 9, 2012
同时对结核病和COVID-19从单个唾液样本进行测试,以加强疾病检测
Anura David1, Leisha Genade2, Lesley Erica Scott1
1Wits Diagnostic Innovation Hub, Health Sciences Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Diagnostics (Basel, Switzerland)
|March 28, 2025
概括
使用单个唾液样本进行结核病 (TB) 和SARS-CoV-2综合检测,发现了大量结核病和并发病例. 这种方法在同时诊断呼吸道疾病方面被证明是有效的.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 诊断微生物学 诊断微生物学
背景情况:
- 结核病 (TB) 和SARS-CoV-2共享重叠的症状和传播途径,使诊断复杂化.
- 建议对高结核病负担的国家采取综合检测策略,以应对共感染.
- 同时对呼吸道病原体进行测试对于有效的疾病管理至关重要.
研究的目的:
- 为了评估单个唾液测试对SARS-CoV-2和Mycobacterium结核病综合体 (MTBC) 的诊断准确性.
- 为了评估Xpert Xpress SARS-CoV-2测试的性能,使用唾液抽样捕获方法.
- 在南非人口中确定结核病和结核病-COVID-19联合感染的流行率.
主要方法:
- 共有1032名患有呼吸道症状或风险因素的参与者提供了唾液进行测试.
- 使用Xpert Xpress SARS-CoV-2试验和Xpert MTB/RIF Ultra试验进行了的测试.
- 一致性分析将Xpress测定结果与常规SARS-CoV-2测试进行了比较.
主要成果:
- 在18%的参与者中检测到SARS-CoV-2,在3%的参与者中检测到结核病.
- 观察到结核病和COVID-19的同时感染率为1%.
- 埃克斯普雷斯试验与常规的SARS-CoV-2检测有很大的一致性 (卡帕:0.755).
结论:
- 综合唾液检测显著发现了可能错过的结核病和抗利芬素结核病病例.
- 唾液抽样捕获方法是SARS-CoV-2检测的可靠方法.
- 同时测试可以提高共感染的检测,并改善患者的治疗结果.
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